反应详情

4-Methoxy-2-methyl-1H-indole (805 mg, 5 mmol) was added to a mixture of 200 mg (5 mmol) of 60% sodium hydride/mineral oil (washed with hexane before adding DMF) in 10 mL of DMF and after stirring for 0.5 hours, 0.6 mL (5 mmol) of 4-fluorobenzyl chloride was added. The mixture was stirred at room temperature for 18 hours, diluted with water-and extracted with ethyl acetate. The ethyl acetate solution was washed with brine, dried (MgSO4) and after concentrating at reduced pressure, the residue was chromatographed on silica gel eluting with 20% EtOAc/hexane to give 1.1 g (84% yield) of 1-[(4-fluorophenyl)methyl]-4-methoxy-2-methyl-1H-indole, melting at 104°-108° C.

1. stirringThe mixture was stirred at room temperature for 18 hours
2. extractionextracted with ethyl acetate
3. washThe ethyl acetate solution was washed with brine
4. dry with materialdried (MgSO4)
5. concentrationafter concentrating at reduced pressure
6. customthe residue was chromatographed on silica gel eluting with 20% EtOAc/hexane