Hydrochloric Acid → HCID 23144495, compound

HRID 337430Notes

Reaction equation

HRID 337430 reaction equation
C([O:3][C:4]([C:6]1[S:10][C:9]([NH:11][C:12]([C:14]2[CH:19]=[CH:18][N:17]=[CH:16][CH:15]=2)=[O:13])=[N:8][C:7]=1[C:20]1[O:21][CH:22]=[CH:23][CH:24]=1)=[O:5])C.[Na].[OH-].Cl>C1COCC1.CO>[C:4]([C:6]1[S:10][C:9]([NH:11][C:12]([C:14]2[CH:15]=[CH:16][N:17]=[CH:18][CH:19]=2)=[O:13])=[N:8][C:7]=1[C:20]1[O:21][CH:22]=[CH:23][CH:24]=1)([OH:5])=[O:3]

Participants

7

Reactant 4

HCID 313Hydrochloric AcidHCID 961HydroxideHCID 5360545SodiumHCID 23144771HCID 23144771, compound

Product 1

HCID 23144495HCID 23144495, compoundYield 53.2%

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 8028TetrahydrofuranSolvent

Conditions

Temperature
60 °C

Procedure

Compound 24 (840 mg, 2.45 mmol) was dissolved in THF (5 mL) and methanol (5 mL), and a 4 mol/L aqueous sodium of hydroxide solution (3 mL) was added thereto, followed by stirring at 60° C. for 2 hours. The reaction mixture was allowed to cool down, and neutralized with 2 mol/L hydrochloric acid added thereto. The precipitated solid was collected by filtration to afford the entitled Compound 95 (411 mg, 53%).

Workup

  1. temperatureto cool down
  2. additionadded
  3. filtrationThe precipitated solid was collected by filtration

Sources & evidence

ORD record
ord-68246349649f423180baf234d4b560b2
Source dataset
uspto-grants-2014_11
Patent number
US08889718B2

Reaction notes

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