反应详情

To a stirred solution of 4-chloro-3-methylphenol (1 eq.) in DMF (0.7 M) was added K2CO3 (1.2 eq.). The mixture was stirred at 50° C. for 5 min before 1-bromo-2-methoxyethane (1.5 eq.) was added. After 2 h at 70° C., the reaction mixture was cooled down to RT and then diluted with water and ether. The organic phase was separated and washed sequentially with 2 N aq. NaOH, water and brine. The organic extract was dried over Na2SO4, filtered and the filtrate concentrated in vacuo to afford the title compound as a yellowish oil.

1. additionwas added
2. customThe organic phase was separated
3. washwashed sequentially with 2 N aq. NaOH, water and brine
4. extractionThe organic extract
5. dry with materialwas dried over Na2SO4
6. filtrationfiltered
7. concentrationthe filtrate concentrated in vacuo