Hydrochloric Acid → HCID 89962578, compound

HRID 337829Notes

Reaction equation

HRID 337829 reaction equation
[CH3:1][C:2]1([CH3:18])[CH2:11][C:6]2(OCC[O:7]2)[C:5]([C:12]2[N:16]([CH3:17])[N:15]=[CH:14][CH:13]=2)=[CH:4][CH2:3]1.Cl>C1COCC1>[CH3:1][C:2]1([CH3:18])[CH2:11][C:6](=[O:7])[C:5]([C:12]2[N:16]([CH3:17])[N:15]=[CH:14][CH:13]=2)=[CH:4][CH2:3]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 89963338HCID 89963338, compound

Product 1

HCID 89962578HCID 89962578, compoundYield 93.3%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

The reaction and aftertreatment were conducted in the same manner as in Example 67c by using the 5-(9,9-dimethyl-1,4-dioxaspiro[4.5]dec-6-en-6-yl)-1-methyl-1H-pyrazole (758 mg, 3.05 mmol) prepared in Example 72b, 2 M hydrochloric acid (2.0 mL) and THF (5.0 mL), to yield the title compound (581 mg, 93%) as a colorless oil.

Workup

  1. customThe reaction and aftertreatment

Sources & evidence

ORD record
ord-1affef71a922431fa8aa9e3f1758d636
Source dataset
uspto-grants-2014_11
Patent number
US08889741B2

Reaction notes

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