Hydrochloric Acid → 2-(3-Aminopyridazin-4-yl)cyclohex-2-en-1-one

HRID 337844Notes

Reaction equation

HRID 337844 reaction equation
O1[C:5]2([CH2:10][CH2:9][CH2:8][CH:7]=[C:6]2[C:11]2[CH:16]=[CH:15][N:14]=[N:13][C:12]=2[NH2:17])[O:4]CC1.Cl>C1COCC1>[NH2:17][C:12]1[N:13]=[N:14][CH:15]=[CH:16][C:11]=1[C:6]1[C:5](=[O:4])[CH2:10][CH2:9][CH2:8][CH:7]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 899634384-(1,4-Dioxaspiro[4.5]dec-6-en-6-yl)pyridazin-3-amine

Product 1

HCID 899630522-(3-Aminopyridazin-4-yl)cyclohex-2-en-1-oneYield 99%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

The reaction and aftertreatment were conducted in the same manner as in Example 67c by using the crude 4-(1,4-dioxaspiro[4.5]dec-6-en-6-yl)pyridazin-3-amine prepared in Example 82c, 2 M hydrochloric acid (0.37 mL) and THF (0.92 mL), to yield the title compound (69 mg, 99%, 2 steps) as a colorless oil.

Workup

  1. customThe reaction and aftertreatment

Sources & evidence

ORD record
ord-634844d5f118469f94b3e0d13a3fb54f
Source dataset
uspto-grants-2014_11
Patent number
US08889741B2

Reaction notes

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