反应详情

温度

120 °C

A solution of ethyl 3-{[1-(biphenyl-4-ylmethyl)-4,6-difluoro-5-iodo-1H-benzimidazol-2-yl]oxy}cyclobutanecarboxylate (0.350 g, 0.595 mmol), biphenylboronic acid (0.130 g, 0.654 mmol), and Pd(PPh3)4 (0.027 g, 0.024 mmol) in 6 mL of DMF was treated with a 1 M solution of K2CO3 (1.20 mL). The resulting yellow solution was heated at 120° C. for 45 min, and then diluted with EtOAc and H2O. The layers were separated and the aqueous layer was extracted with EtOAc. The combined organic layers were washed with brine, dried over Na2SO4, filtered, and concentrated. Purification of the resulting residue by flash chromatography (0-15% then 15-20% then 20% EtOAc/hexanes) provided the desired product as a white solid. LCMS: calculated for C39H32F2N2O3 614.68, observed ink 615.1 (M+H)+ (Rt 2.79/4 min).

1. customThe layers were separated
2. extractionthe aqueous layer was extracted with EtOAc
3. washThe combined organic layers were washed with brine
4. dry with materialdried over Na2SO4
5. filtrationfiltered
6. concentrationconcentrated
7. customPurification of the resulting residue by flash chromatography (0-15%