Benzaldehyde → DL-beta-Phenylalanine

HRID 341760Notes

Reaction equation

HRID 341760 reaction equation
[CH:1](=O)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[C:9]([OH:15])(=[O:14])[CH2:10]C(O)=O.C([O-])(=O)C.[NH4+:20]>C(O)C>[CH:5]1[CH:6]=[CH:7][C:2]([CH:1]([NH2:20])[CH2:10][C:9]([OH:15])=[O:14])=[CH:3][CH:4]=1

Participants

5

Reactant 3

HCID 240BenzaldehydeHCID 867Malonic AcidHCID 517165Ammonium Acetate

Product 1

HCID 69189DL-beta-Phenylalanine

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A suspension of 100 g of benzaldehyde, 94 g of malonic acid, 109 g of ammonium acetate in 300 cm3 of ethanol, is brought to boiling point in a nitrogen atmosphere, under vigorous stirring. The suspension is mantained under the above conditions for about eight hours.

Sources & evidence

ORD record
ord-66fb23c058584097a0d7ac31bac82c6e
Source dataset
uspto-grants-1999_01
Patent number
US05856311

Reaction notes

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