Hydrochloric Acid → HCID 22941049, compound

HRID 342114Notes

Reaction equation

HRID 342114 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][N:11]([C:14]([C:16]2[C:25]3[C:20](=[CH:21][CH:22]=[CH:23][CH:24]=3)[CH:19]=[CH:18][CH:17]=2)=[O:15])[CH2:10][C@@H:9]1[CH2:26][CH2:27][CH2:28][CH3:29])=O)(C)(C)C.[ClH:30]>C(OCC)(=O)C>[ClH:30].[CH2:26]([C@H:9]1[CH2:10][N:11]([C:14]([C:16]2[C:25]3[C:20](=[CH:21][CH:22]=[CH:23][CH:24]=3)[CH:19]=[CH:18][CH:17]=2)=[O:15])[CH2:12][CH2:13][NH:8]1)[CH2:27][CH2:28][CH3:29]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 67590219HCID 67590219, compound

Product 1

HCID 22941049HCID 22941049, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Conditions

Temperature
-40 °C

Procedure

The product from Step D was dissolved in ethyl acetate, cooled to -40° C. under nitrogen, and the solution saturated with HCl(g). The solution was warmed to 0° C. for 30 min, and then purged with nitrogen. The solvent was removed in vacuo. The product was evaporated from ethyl acetate three times. The title compound was obtained as a white solid.

Workup

  1. temperatureThe solution was warmed to 0° C. for 30 min
  2. custompurged with nitrogen
  3. customThe solvent was removed in vacuo
  4. customThe product was evaporated from ethyl acetate three times

Sources & evidence

ORD record
ord-9fc8c200f1be403b98f731ba62843ecb
Source dataset
uspto-grants-1999_01
Patent number
US05856326

Reaction notes

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