反应详情

Metal magnesium in an amount of 11.6 g was suspended in 100 ml of tetrahydrofuran (hereinafter referred to as THF) under nitrogen gas stream, and a solution prepared by dissolving 69 g of bromobenzene in 200 ml of THF was added dropwise in the suspension and then stirred at room temperature for 1 hour. A solution prepared by dissolving 100 g of 4-(2-(trans-4-n-propylcyclohexyl)ethyl)cyclohexanone in 300 ml of THF was added dropwise thereto and stirred at room temperature for 1 hour. After finishing of the reaction, 500 ml of dilute hydrochloric acid was added thereto and extracted with 1 l of ethyl acetate. Organic layer was washed with water and dried over anhydrous magnesium sulfate, and the solvent was distilled off under a reduced pressure to obtain 119 g of (1-hydroxy-4-(2-(trans-4-n-propylcyclohexyl)ethyl)cyclohexyl)benzene.

1. customa solution prepared
2. additionwas added dropwise in the suspension
3. customA solution prepared
4. additionwas added dropwise
5. stirringstirred at room temperature for 1 hour
6. additionwas added
7. extractionextracted with 1 l of ethyl acetate
8. washOrganic layer was washed with water
9. dry with materialdried over anhydrous magnesium sulfate
10. distillationthe solvent was distilled off under a reduced pressure