Hydrochloric Acid → 3-(2-Ethoxycarbonyl-3-oxobutyl)-2-methyl-7-nitrobenzo[b]furan
Reaction equation
[Na].[C:2]([O:8][CH2:9][CH3:10])(=[O:7])[CH2:3][C:4]([CH3:6])=[O:5].Cl[CH2:12][C:13]1[C:14]2[CH:22]=[CH:21][CH:20]=[C:19]([N+:23]([O-:25])=[O:24])[C:15]=2[O:16][C:17]=1[CH3:18].Cl>C(O)C.O>[CH2:9]([O:8][C:2]([CH:3]([C:4](=[O:5])[CH3:6])[CH2:12][C:13]1[C:14]2[CH:22]=[CH:21][CH:20]=[C:19]([N+:23]([O-:25])=[O:24])[C:15]=2[O:16][C:17]=1[CH3:18])=[O:7])[CH3:10]Participants
7
Reactant 4
Product 1
Reagents, catalysts & solvents 2
Conditions
- Temperature
- 60 °C
Procedure
To a solution of sodium (52 mg) in ethanol (5 ml) was added ethyl acetoacetate (293 mg) and 3-chloromethyl-2-methyl-7-nitrobenzo[b]furan (339 mg). The mixture was stirred at 60° C. for 3 hours, cooled and poured into cold water. The pH of the aqueous solution was adjusted to 3 with 1N-hydrochloric acid and the separated oil was extracted with dichloromethane. The extract was washed with brine, dried over sodium sulfate and concentrated in vacuo. The residue was purified by column chromatography on silica gel and the obtained oil was crystallized from n-hexane to give 3-(2-ethoxycarbonyl-3-oxobutyl)-2-methyl-7-nitrobenzo[b]furan (205 mg).
Workup
- temperaturecooled
- extractionthe separated oil was extracted with dichloromethane
- washThe extract was washed with brine
- dry with materialdried over sodium sulfate
- concentrationconcentrated in vacuo
- customThe residue was purified by column chromatography on silica gel
- customthe obtained oil was crystallized from n-hexane
Sources & evidence
- ORD record
- ord-c4129d167fd34e9bb66410e4d0cefc37
- Source dataset
- uspto-grants-1999_01
- Patent number
- US05858995
Reaction notes
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