反应详情

A solution of benzaldehyde (6.5g, 0.0617 mole), 3-methyl-1-phenyl-2-butanone (10 g, 0.0617 mole) and piperidine (0.2 g) in benzene (50 ml) was heated to reflux for 20 hours. Water formed during the reaction was removed (azeotrope) by the use of a Dean-Stark trap. The reaction was concentrated to an oil, and the product was purified by silica gel chromatography.

1. temperatureto reflux for 20 hours
2. customwas removed (azeotrope) by the use of a Dean-Stark trap
3. concentrationThe reaction was concentrated to an oil
4. customthe product was purified by silica gel chromatography