反应详情

温度

70 °C

A stirred mixture of 4-iodophenol (0.50 g, 2.27 mmol), methyl 2-bromoacetate (0.382 g, 2.50 mmol), and powdered potassium carbonate (0.314 g, 2.27 mmol) in dry acetone under argon was sealed and heated at 70° C. for 4 hr. The cooled mixture was filtered, and the filtrate was evaporated in vacuo. The residue was purified by chromatography (silica, 40 to 50% methylene chloride in cyclohexane) and the solvent was removed in vacuo to afford the titled intermediate as a white solid (0.41 g, 62%), mp 69°-70° C.

1. customwas sealed
2. filtrationThe cooled mixture was filtered
3. customthe filtrate was evaporated in vacuo
4. customThe residue was purified by chromatography (silica, 40 to 50% methylene chloride in cyclohexane)
5. customthe solvent was removed in vacuo