Hydrochloric Acid → HCID 52983856, compound

HRID 343982Notes

Reaction equation

HRID 343982 reaction equation
[CH2:1]([NH:8][C:9](=[O:15])[C@@H:10]1[CH2:14][CH2:13][CH2:12][NH:11]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[ClH:16]>C(O)(C)C>[ClH:16].[CH2:1]([NH:8][C:9](=[O:15])[C@@H:10]1[CH2:14][CH2:13][CH2:12][NH:11]1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 11790329HCID 11790329, compound

Product 1

HCID 52983856HCID 52983856, compound

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent2×

Procedure

413 g of the proline benzylamide obtained in this way were dissolved in 400 ml of isopropanol. 630 ml of a saturated solution of HCl in isopropanol were added, the resulting suspension was stirred at 0°-5° C. for 2 h, and the solid was filtered off with suction and washed twice with 250 ml of isopropanol. The residue was dried at 50° C. under reduced pressure to obtain 401 g of proline benzylamide hydrochloride; aD20 :--45°

Workup

  1. filtrationthe solid was filtered off with suction
  2. washwashed twice with 250 ml of isopropanol
  3. customThe residue was dried at 50° C. under reduced pressure

Sources & evidence

ORD record
ord-bb7f50ff02fe4e57899ed09eb9ce56ec
Source dataset
uspto-grants-1999_01
Patent number
US05864012

Reaction notes

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