3,5-Dimethylpyrazole → 3,5-Dimethylpyrazole

HRID 344678Notes

Reaction equation

HRID 344678 reaction equation
[CH3:1][C:2]1[CH:6]=[C:5]([CH3:7])[NH:4][N:3]=1.Br[CH2:9][CH2:10][Cl:11].BrCCBr>O1CCCC1>[CH3:1][C:2]1[CH:6]=[C:5]([CH3:7])[N:4]([CH2:9][CH2:10][Cl:11])[N:3]=1.[CH3:1][C:2]1[CH:6]=[C:5]([CH3:7])[NH:4][N:3]=1

Participants

6

Reactant 3

HCID 62103,5-DimethylpyrazoleHCID 78391,2-DibromoethaneHCID 78491-Bromo-2-Chloroethane

Product 2

HCID 62103,5-DimethylpyrazoleHCID 11499791-(2-chloroethyl)-3,5-dimethyl-1H-pyrazole

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

When an equivalent amount of 3,5-dimethylpyrazole is substituted for 1-ethoxycarbonyl-2H-indazolin-3-one and 2-bromochloroethane is substituted for 1,2-dibromoethane in the procedure of Example 19 using tetrahydrofuran as solvent, 2-(3,5-dimethyl-1H-pyrazol-1-yl)ethyl chloride is isolated after column chromatography (3,5-dimethylpyrazole, Aldrich, 24%, C).

Sources & evidence

ORD record
ord-3a829151118043718252442deb88f81b
Source dataset
uspto-grants-1991_10
Patent number
US05053411

Reaction notes

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