HRID34502

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID7914

Isopropyl ether

C6H14O

HCID8454

N-Methylpyrrolidine

C5H11N

结构：O=C(NC1C(=O)N2C(C(=O)OC(c3ccccc3)c3ccccc3)=C(CI)CS(=O)[C@H]12)C(=NOC(F)F)c1csc(NC(c2ccccc2)(c2ccccc2)c2ccccc2)n1

HCID131715683

未命名化合物

PRODUCTS

生成物

结构：CC(C1=C(C(=O)OC(c2ccccc2)c2ccccc2)N2C(=O)C(NC(=O)C(=NOC(F)F)c3csc(NC(c4ccccc4)(c4ccccc4)c4ccccc4)n3)[C@H]2S(=O)C1)[NH+]1CCCC1.[I-]

HCID131715681

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID8028

Tetrahydrofuran

C4H8O

PROCEDURE

实验过程

A solution of benzhydryl 7-[2-(2-tritylaminothiazol-4-yl)-2-difluoromethoxyiminoacetamido]-3-iodomethyl-3-cephem-4-carboxylate-1-oxide (syn isomer) (1.97 g) and N-methylpyrrolidine (204 mg) in tetrahydrofuran (10 ml) was stirred for 40 minutes at 0°-5° C. and then diisopropyl ether was added thereto. The resultant precipitates were collected by filtration, washed with diisopropyl ether and air-dried to give benzhydryl 7-[2-(2-tritylaminothiazol-4-yl)-2-difluoromethoxyiminoacetamido]-3-(1-methyl-1-pyrrolidiniomethyl)-3-cephem-4-carboxylate-1-oxide iodide (syn isomer) (2.12 g).

WORKUP

后处理

customThe resultant precipitates
filtrationwere collected by filtration
washwashed with diisopropyl ether
customair-dried

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-7fa97aacc8b343b488a1eb5df8f9f917
来源数据集: uspto-grants-1988_08
DOI: 10.6084/m9.figshare.5104873.v1
专利: US04761410
来源说明: uspto-grants-1988_08

反应 SMILES

[C:1]([NH:20][C:21]1[S:22][CH:23]=[C:24]([C:26](=[N:58][O:59][CH:60]([F:62])[F:61])[C:27]([NH:29][CH:30]2[C:56](=[O:57])[N:32]3[C:33]([C:40]([O:42][CH:43]([C:50]4[CH:55]=[CH:54][CH:53]=[CH:52][CH:51]=4)[C:44]4[CH:49]=[CH:48][CH:47]=[CH:46][CH:45]=4)=[O:41])=[C:34]([CH2:38][I:39])[CH2:35][S:36](=[O:37])[C@H:31]23)=[O:28])[N:25]=1)([C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1)([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.C[N:64]1[CH2:68][CH2:67][CH2:66][CH2:65]1.[CH:69](OC(C)C)(C)C>O1CCCC1>[I-:39].[C:1]([NH:20][C:21]1[S:22][CH:23]=[C:24]([C:26](=[N:58][O:59][CH:60]([F:62])[F:61])[C:27]([NH:29][CH:30]2[C:56](=[O:57])[N:32]3[C:33]([C:40]([O:42][CH:43]([C:50]4[CH:55]=[CH:54][CH:53]=[CH:52][CH:51]=4)[C:44]4[CH:49]=[CH:48][CH:47]=[CH:46][CH:45]=4)=[O:41])=[C:34]([CH:38]([CH3:69])[NH+:64]4[CH2:68][CH2:67][CH2:66][CH2:65]4)[CH2:35][S:36](=[O:37])[C@H:31]23)=[O:28])[N:25]=1)([C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1)([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1