反应详情

1-Methylcarbamoylisatin (10.2 g) and 1,8-diazabicyclo[5.4.0]-7-undecene (0.3 g) are dissolved in tetrahydrofuran (100 ml), and thereto is added urea (4.5 g), and the mixture is refluxed for 10 hours. After cooling, the precipitates are taken by filtration, washed with water and methanol and recrystallized from a mixture of dimethylsulfoxide and ethanol to give 3-methyl-4-hydroxy-4-ureidocarbonyl-2-oxo-1,2,3,4-tetrahydroquinazoline, M.p.>280° C.,

1. temperaturethe mixture is refluxed for 10 hours
2. temperatureAfter cooling
3. filtrationthe precipitates are taken by filtration
4. washwashed with water and methanol
5. customrecrystallized from a mixture of dimethylsulfoxide and ethanol