反应详情

To a solution of 23.4 g of indole in 200 ml of DMF, cooled to 10° C., were added 22.4 g of potassium hydroxide and 101 g of 1,3-dibromopropane. The mixture was stirred under nitrogen for 3 days. The solid formed was filtered off and the filtrate was evaporated. The residue was chromatographed on silica gel with 5% diethyl ether in petroleum ether to give 14.7 g of 1-(3-bromopropyl)indole.

1. customThe solid formed
2. filtrationwas filtered off
3. customthe filtrate was evaporated
4. customThe residue was chromatographed on silica gel with 5% diethyl ether in petroleum ether