反应详情

A solution of 50 g free sertraline base in 100 ml of n-propanol was added dropwise over a period of about 30 minutes at ambient temperature onto 100 ml of n-propanol containing 13 ml of 37% aqueous hydrochloric acid. About 10 minutes after the end of the addition a white crystalline solid starts to form. Stirring is maintained for 1 hour then the solid is filtered and washed. It is dried under vacuum. 47.5 g of sertraline hydrochloride form II are obtained in a 85% yield.

1. additionAbout 10 minutes after the end of the addition a white crystalline solid starts
2. customto form
3. temperatureis maintained for 1 hour
4. filtrationthe solid is filtered
5. washwashed
6. customIt is dried under vacuum