反应详情

A solution of 51.4 g free sertraline base in 100 ml of n-pentanol was added dropwise over a period of about 30 minutes at room temperature onto 100 ml of n-pentanol containing 13 ml of 37% aqueous hydrochloric acid. About ¾ of the way through the addition a white crystalline solid starts to form. Stirring is maintained for 1 hour then the solid is filtered and washed. It is dried under vacuum. 50 g of sertraline hydrochloride form II are obtained in a yield of 87%.

1. additionAbout ¾ of the way through the addition a white crystalline solid starts
2. customto form
3. temperatureis maintained for 1 hour
4. filtrationthe solid is filtered
5. washwashed
6. customIt is dried under vacuum