反应详情

温度

45 °C

A solution of 15 ml of aqueous hydrochloric acid 37% in 100 ml of n-propanol was heated at 45° C. and a solution of 50 g free sertraline base in 100 ml of n-propanol was added dropwise over a period of about 30 minutes. About 20 minutes after the end of the addition a white crystalline solid starts to form. The suspension is stirred for 1 hour at 45° C., then cooled to room temperature within 1 hour. The solid is filtered, washed and dried under vacuum. 49.2 g of sertraline hydrochloride form II are obtained in a 88% yield.

1. additionAbout 20 minutes after the end of the addition a white crystalline solid starts
2. customto form
3. temperaturecooled to room temperature within 1 hour
4. filtrationThe solid is filtered
5. washwashed
6. customdried under vacuum