反应详情

2-Bromopyridine (1.98 mL, 20.0 mmol), ethyl 4-hydroxybenzoate (6.71 g, 40.0 mmol) and potassium carbonate (2.78 g, 20.0 mmol) were mixed and the mixture was stirred for 6 hours at 150° C. to 160° C. After allowed to stand for cooling, 20 mL of 8% aqueous solution of sodium hydroxide were added to the reaction mixture, which was extracted with diethyl ether. The extracted solution was dried over anhydrous sodium sulfate and then concentrated. The residue was purified by silica gel chromatography (eluate n-hexane:ethyl acetate=10:1 v/v) to obtain 1.26 g (26%) of the title compound as a colorless oil.

1. temperaturefor cooling
2. extractionwas extracted with diethyl ether
3. dry with materialThe extracted solution was dried over anhydrous sodium sulfate
4. concentrationconcentrated
5. customThe residue was purified by silica gel chromatography (eluate n-hexane:ethyl acetate=10:1 v/v)