反应详情

温度

140 °C

Process variant b) describes the reaction of a compound of formula II-2 with 1-methylpiperazine to produce a compound of formula I-2. A mixture of 2-(3,5-bis-trifluoromethyl-phenyl)-N-(6′-chloro-2-methyl-[3,4′]bipyridinyl-3′-yl)-N-methyl-isobutyramide, 1-methylpiperazine and 4-(N,N-dimethylamino)pyridine is heated at about 140° C. over night. After cooling to room temperature, the mixture is diluted with tert-butyl methyl ether and washed with water. The aqueous layer is extracted with tert-butyl methyl ether. The combined organic layers are dried and concentrated to give the compound 2-(3,5-bis-trifluoromethyl-phenyl)-N-methyl-N-[2-methyl-6′-(4-methyl-piperazin-1-yl)-[3,4′]bipyridinyl-3′-yl]-isobutyramide of formula I-2.

1. customto produce a compound of formula I-2
2. temperatureAfter cooling to room temperature
3. washwashed with water
4. extractionThe aqueous layer is extracted with tert-butyl methyl ether
5. customThe combined organic layers are dried
6. concentrationconcentrated