Triethylamine → HCID 58801124, compound

HRID 347723Notes

Reaction equation

HRID 347723 reaction equation
[CH2:1]([O:3][C:4]([CH:6]1[CH2:11][CH2:10][NH:9][CH2:8][CH2:7]1)=[O:5])[CH3:2].[NH2:12][C:13]1[N:18]=[C:17](Cl)[CH:16]=[C:15]([CH3:20])[N:14]=1.C(N(CC)CC)C>C(O)C>[CH2:1]([O:3][C:4]([CH:6]1[CH2:11][CH2:10][N:9]([C:17]2[CH:16]=[C:15]([CH3:20])[N:14]=[C:13]([NH2:12])[N:18]=2)[CH2:8][CH2:7]1)=[O:5])[CH3:2]

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 218102-Amino-4-chloro-6-methylpyrimidineHCID 70770Ethyl 4-piperidinecarboxylate

Product 1

HCID 58801124HCID 58801124, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A solution of 4-piperidinecarboxylic acid ethyl ester (6.6 g), 2-amino-4-chloro-6-methylpyrimidine (5.0 g) and triethylamine (4.2 g) in ethanol (50 ml) is stirred at 90° C. for 3 hours. Ethanol is evaporated under reduced pressure, and the residue is dissolved in chloroform, and washed with water. The organic layer is concentrated under reduced pressure to give the title compound.

Workup

  1. customEthanol is evaporated under reduced pressure
  2. dissolutionthe residue is dissolved in chloroform
  3. washwashed with water
  4. concentrationThe organic layer is concentrated under reduced pressure

Sources & evidence

ORD record
ord-d2703f16d5d74007a07415b5d572fb51
Source dataset
uspto-grants-2007_02
Patent number
US07176199B2

Reaction notes

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