反应详情

In DMF (40 ml), methyl 3,4-diaminobenzoate (2.01 g) was dissolved and then the solution was added with potassium carbonate (2.00 g) and 1-iodopropane (1.4 ml), followed by stirring at room temperature for 22 hours. After completion of the reaction, the solvent was distilled off under reduced pressure. The residue was dissolved in ethyl acetate and washed with water, followed by extraction with ethyl acetate. The organic layer was washed with saturated saline solution and dried with anhydrous sodium sulfate. After filtration, the solvent was distilled off under reduced pressure and the residue was then purified through silica gel column chromatography (hexane/ethyl acetate), thereby obtaining the subject compound (1.06 g).

1. customAfter completion of the reaction
2. distillationthe solvent was distilled off under reduced pressure
3. dissolutionThe residue was dissolved in ethyl acetate
4. washwashed with water
5. extractionfollowed by extraction with ethyl acetate
6. washThe organic layer was washed with saturated saline solution
7. dry with materialdried with anhydrous sodium sulfate
8. filtrationAfter filtration
9. distillationthe solvent was distilled off under reduced pressure
10. customthe residue was then purified through silica gel column chromatography (hexane/ethyl acetate)