Diisopropylethylamine → N-(3-Amino-4-thienyl)-N'-(2-chloro-6-methylphenyl)thiourea

HRID 349426Notes

Reaction equation

HRID 349426 reaction equation
C(N(C(C)C)C(C)C)C.Br.Br.[NH2:12][C:13]1[C:17]([NH2:18])=[CH:16][S:15][CH:14]=1.[Cl:19][C:20]1[CH:25]=[CH:24][CH:23]=[C:22]([CH3:26])[C:21]=1[N:27]=[C:28]=[S:29]>C1COCC1>[NH2:12][C:13]1[C:17]([NH:18][C:28]([NH:27][C:21]2[C:22]([CH3:26])=[CH:23][CH:24]=[CH:25][C:20]=2[Cl:19])=[S:29])=[CH:16][S:15][CH:14]=1

Participants

5

Reactant 3

HCID 81531DiisopropylethylamineHCID 37317252-Chloro-6-Methylphenyl IsothiocyanateHCID 21989329Thiophene-3,4-diamine dihydrobromide

Product 1

HCID 86037747N-(3-Amino-4-thienyl)-N'-(2-chloro-6-methylphenyl)thiourea

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

was obtained in a similar manner to the method specified in Example 6a) by reacting a mixture prepared from 0.74 g (=1.01 ml) of N-ethyl-N,N-diisopropylamine in 40 ml of THF, 0.8 g of 3,4-diaminothiophene dihydrobromide and 0.473 g of 2-chloro-6-methylphenyl isothiocyanate.

Workup

  1. customwas obtained in a similar manner to the method

Sources & evidence

ORD record
ord-b6d010019dc9429985c7dd2cf43e51ec
Source dataset
uspto-grants-2007_02
Patent number
US07179830B2

Reaction notes

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