反应详情

A suspension of 17.5 g (ca. 46 mM) of 8α-benzyloxycarbonylaminoergoline obtained from step (c), 13.5 g potassium carbonate and 6 ml (62 mM) n-propyl iodide in 300 ml dimethylformamide is stirred for 18 hours at room temperature. The mixture is filtered and concentrated in a rotary evaporator. The residue is treated with methylene chloride and shaken with water. The organic phase is dried over sodium sulphate, filtered and concentrated to give the crude heading compound.

1. filtrationThe mixture is filtered
2. concentrationconcentrated in a rotary evaporator
3. additionThe residue is treated with methylene chloride
4. stirringshaken with water
5. dry with materialThe organic phase is dried over sodium sulphate
6. filtrationfiltered
7. concentrationconcentrated
8. customto give the crude