Potassium Carbonate → 4-((Allyl(methyl)amino)methyl)thiazol-2-amine

HRID 350959Notes

Reaction equation

HRID 350959 reaction equation
[CH2:1]([NH:4][CH3:5])[CH:2]=[CH2:3].Cl.[NH2:7][C:8]1[S:9][CH:10]=[C:11]([CH2:13]Cl)[N:12]=1.C(=O)([O-])[O-].[K+].[K+]>C(O)C>[CH2:1]([N:4]([CH2:13][C:11]1[N:12]=[C:8]([NH2:7])[S:9][CH:10]=1)[CH3:5])[CH:2]=[CH2:3]

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 69391N-MethylallylamineHCID 732282-Thiazolamine, 4-(chloromethyl)-, hydrochloride (1:1)

Product 1

HCID 210906034-((Allyl(methyl)amino)methyl)thiazol-2-amine

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

N-allyl-N-methylamine (7.0 mg, 0.1 mmol), 2-amino-4-chloromethylthiazole hydrochloride (18.5 mg, 0.1 mmol), and potassium carbonate (30 mg, 0.21 mmol) are shaken in ethanol (1 mL) at room temperature for 18 hours. The mixture is filtered and the filtrate was condensed under vacuum.

Workup

  1. filtrationThe mixture is filtered
  2. customcondensed under vacuum

Sources & evidence

ORD record
ord-6de76e9d87074e8c81db3041feaa73dd
Source dataset
uspto-grants-2007_02
Patent number
US07183300B2

Reaction notes

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