Dimethylformamide → HCID 21091167, compound

HRID 351195Notes

Reaction equation

HRID 351195 reaction equation
CS(Cl)(=O)=O.C(N(CC)CC)C.O[C:14]([C:17]1[CH:21]=[C:20]([C:22]2[CH:38]=[CH:37][C:25]([O:26][CH2:27][CH2:28][NH:29][C:30](=[O:36])[O:31][C:32]([CH3:35])([CH3:34])[CH3:33])=[CH:24][CH:23]=2)[N:19]([C:39]2[CH:44]=[CH:43][C:42]([O:45][CH3:46])=[CH:41][CH:40]=2)[N:18]=1)([CH3:16])[CH3:15].CN(C)C=O>ClCCl>[C:14]([C:17]1[CH:21]=[C:20]([C:22]2[CH:23]=[CH:24][C:25]([O:26][CH2:27][CH2:28][NH:29][C:30](=[O:36])[O:31][C:32]([CH3:35])([CH3:34])[CH3:33])=[CH:37][CH:38]=2)[N:19]([C:39]2[CH:44]=[CH:43][C:42]([O:45][CH3:46])=[CH:41][CH:40]=2)[N:18]=1)([CH3:16])=[CH2:15]

Participants

6

Reactant 4

HCID 6228DimethylformamideHCID 8471Triethylamine2×HCID 31297Methanesulfonyl chloride2×HCID 21091163HCID 21091163, compound

Product 1

HCID 21091167HCID 21091167, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Methanesulfonyl chloride (367 mg) and triethylamine (649 mg) were added successively to a solution of tert-butyl 2-{4-[3-(1-hydroxy-1-methylethyl)-1-(4-methoxy-phenyl)-1H-pyrazol-5-yl]phenoxy}ethylcarbamate obtained by Example 6 (1.0 g) and N,N-dimethylformamide (91.5 mg) in dichloromethane (10 ml) and the mixture was stirred at room temperature for 2 hrs. Additional methanesulfonyl chloride and triethylamine were added until all starting material was consumed with stirring at the same temperature.

Workup

  1. customwas consumed
  2. stirringwith stirring at the same temperature

Sources & evidence

ORD record
ord-deb6c07a24ac48d581b5c8fc4a052930
Source dataset
uspto-grants-2007_02
Patent number
US07183306B2

Reaction notes

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