Ethanol → HCID 135737383, compound

HRID 351205Notes

Reaction equation

HRID 351205 reaction equation
C([O-])=O.[NH4+].C(O)C.C([O:15][C:16]1[CH:21]=[CH:20][C:19]([C:22]2[N:26]([C:27]3[CH:32]=[CH:31][C:30]([O:33][CH3:34])=[CH:29][CH:28]=3)[N:25]=[C:24]([O:35][CH:36]([CH3:38])[CH3:37])[CH:23]=2)=[CH:18][CH:17]=1)C1C=CC=CC=1>O.O1CCCC1.[Pd]>[CH:36]([O:35][C:24]1[CH:23]=[C:22]([C:19]2[CH:18]=[CH:17][C:16]([OH:15])=[CH:21][CH:20]=2)[N:26]([C:27]2[CH:28]=[CH:29][C:30]([O:33][CH3:34])=[CH:31][CH:32]=2)[N:25]=1)([CH3:38])[CH3:37]

Participants

7

Reactant 3

HCID 702EthanolHCID 2723923Ammonium formateHCID 21091002HCID 21091002, compound

Product 1

HCID 135737383HCID 135737383, compound

Reagents, catalysts & solvents 3

HCID 23938PalladiumCatalystHCID 962WaterSolventHCID 8028TetrahydrofuranSolvent

Procedure

To a solution of ammonium formate (954 mg) in water (2 ml) were added ethanol (10 ml), a solution of 5-[4-(benzyl-oxy)phenyl]-3-isopropoxy-1-(4-methoxyphenyl)-1H-pyrazole obtained by Example 36 (2.09 g) in tetrahydrofuran (10 ml), and 10% palladium on carbon 50% wet (200 mg) successively. The mixture was refluxed for 1 hr.

Workup

  1. temperatureThe mixture was refluxed for 1 hr

Sources & evidence

ORD record
ord-425d52ecb9e94ebe93305b53be008499
Source dataset
uspto-grants-2007_02
Patent number
US07183306B2

Reaction notes

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