Hydrochloric Acid → HCID 135737362, compound

HRID 351227Notes

Reaction equation

HRID 351227 reaction equation
COC[O:4][C:5]1[CH:10]=[CH:9][C:8]([C:11]2[N:15]([C:16]3[CH:21]=[CH:20][C:19]([O:22][CH3:23])=[CH:18][CH:17]=3)[N:14]=[C:13]([S:24]([CH3:27])(=[O:26])=[O:25])[CH:12]=2)=[CH:7][CH:6]=1.Cl>O1CCCC1.C(O)(C)C>[CH3:23][O:22][C:19]1[CH:18]=[CH:17][C:16]([N:15]2[C:11]([C:8]3[CH:9]=[CH:10][C:5]([OH:4])=[CH:6][CH:7]=3)=[CH:12][C:13]([S:24]([CH3:27])(=[O:26])=[O:25])=[N:14]2)=[CH:21][CH:20]=1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 21091005HCID 21091005, compound

Product 1

HCID 135737362HCID 135737362, compoundYield 99.5%

Reagents, catalysts & solvents 2

HCID 3776IsopropanolSolventHCID 8028TetrahydrofuranSolvent

Procedure

To the solution of 5-[4-(methoxymethoxy)phenyl]-1-(4-methoxyphenyl)-3-(methylsulfonyl)-1H-pyrazole (0.93 g) in a mixture of tetrahydrofuran (10 ml) and isopropyl alcohol (5 ml) was added hydrogen chloride aqueous solution (20%, 8 ml) at ambient temperature. The solution was stirred for 3 hours, extracted with ethyl acetate, washed with brine, dried over magnesium sulfate, and evaporated to give 0.82 g of 4-[1-(4-methoxyphenyl)-3-(methylsulfonyl)-1H-pyrazol-5-yl]phenol (P0025).

Workup

  1. extractionextracted with ethyl acetate
  2. washwashed with brine
  3. dry with materialdried over magnesium sulfate
  4. customevaporated

Sources & evidence

ORD record
ord-77dc70607ac3496294f8cfd43711dfda
Source dataset
uspto-grants-2007_02
Patent number
US07183306B2

Reaction notes

Loading…