反应详情

A suspension of 233 mg (0.8 mmol) of Compound 17, 216 mg (1.2 mmol) of 1-(4-fluorophenyl)piperazine, 166 mg (1.2 mmol) of potassium carbonate and 240 mg (1.6 mmol) of sodium iodide in 20 ml of acetonitrile was refluxed for 23 hours. Post-treatment was conducted in a similar manner as in Example 18. The residue was purified by chromatography on a silica gel column (eluent: methanol/chloroform=1/49), whereby 291 mg of the title compound were obtained (yield: 84%).

1. temperaturewas refluxed for 23 hours
2. customThe residue was purified by chromatography on a silica gel column (eluent: methanol/chloroform=1/49)