Furfural → 1-(2-Furyl)-1,4-butanediol

HRID 352129Notes

Reaction equation

HRID 352129 reaction equation
S1[CH:5]=[CH:4][C:3]([CH:6]([OH:11])[CH2:7][CH2:8][CH2:9][OH:10])=C1.[O:12]1C=CC=[C:13]1C=O>O1CCCC1>[O:12]1[CH:13]=[CH:5][CH:4]=[C:3]1[CH:6]([OH:11])[CH2:7][CH2:8][CH2:9][OH:10]

Participants

4

Reactant 2

HCID 7362FurfuralHCID 227150901-(3-Thienyl)-1,4-butanediol

Product 1

HCID 138155341-(2-Furyl)-1,4-butanediol

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

The Grignard reagent prepared in Example 26 step (a) (0.7 M, 28 ml, 19.6 mmol), and furan-2-carboxaldehyde (1.92 g, 20 mmol) in anhydrous tetrahydrofuran (15 ml) were used to prepare the sub-title compound, using the procedure described in Example 26 step (a). The product was a colourless oil (2.69 g, 88%).

Sources & evidence

ORD record
ord-51b020c78196475d8b72e615693d5058
Source dataset
uspto-grants-2004_06
Patent number
US06743939B2

Reaction notes

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