Hydrochloric Acid → HCID 22713722, compound

HRID 352207Notes

Reaction equation

HRID 352207 reaction equation
C[O:2][C:3](=[O:14])[CH2:4][NH:5][C:6]1[CH:7]=[N:8][C:9]([O:12][CH3:13])=[CH:10][CH:11]=1.[OH-].[Li+].Cl>O1CCOCC1.O>[CH3:13][O:12][C:9]1[N:8]=[CH:7][C:6]([NH:5][CH2:4][C:3]([OH:14])=[O:2])=[CH:11][CH:10]=1

Participants

6

Reactant 3

HCID 313Hydrochloric AcidHCID 3939Lithium HydroxideHCID 28564689HCID 28564689, compound

Product 1

HCID 22713722HCID 22713722, compound

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 312751,4-DioxaneSolvent

Procedure

To a solution of (6-methoxy-pyridin-3-ylamino)-acetic acid methyl ester, 113 mg (0.58 mmol) in 10 mL of dioxane was added a solution of 70 mg (2.9 mmol) of lithium hydroxide in 10 mL of water. The reaction mixture was stirred for three hours, acidified to pH=1 with 5 N HCl and concentrated to dryness to yield the crude desired product which was carried on without further purification. MS (IS) 183.1 (M+1).

Workup

  1. concentrationconcentrated to dryness

Sources & evidence

ORD record
ord-30e30f6194a844a1b0b8689fbf4c2a31
Source dataset
uspto-grants-2004_06
Patent number
US06743794B2

Reaction notes

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