Potassium Carbonate → HCID 69836129, compound

HRID 352357Notes

Reaction equation

HRID 352357 reaction equation
C([N:4]1[C:12]2[C:7](=[CH:8][C:9]([O:22][CH3:23])=[C:10]([N:13]3[CH2:18][C@H:17]([CH3:19])[N:16]([CH3:20])[C@H:15]([CH3:21])[CH2:14]3)[CH:11]=2)[CH2:6][CH2:5]1)(=O)C.C([O-])([O-])=O.[K+].[K+]>Cl>[CH3:23][O:22][C:9]1[CH:8]=[C:7]2[C:12](=[CH:11][C:10]=1[N:13]1[CH2:14][C@H:15]([CH3:21])[N:16]([CH3:20])[C@H:17]([CH3:19])[CH2:18]1)[NH:4][CH2:5][CH2:6]2

Participants

4

Reactant 2

HCID 11430Potassium CarbonateHCID 69663924cis-1-Acetyl-5-methoxy-6-(3,4,5-trimethylpiperazin-1-yl)indoline

Product 1

HCID 69836129HCID 69836129, compoundYield 101.7%

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

A stirred solution of D2 (1.6 g, 5 mmole) in 2M HCl acid (50 ml) was heated under reflux for 2 h, then the solution was allowed to cool, basified with K2CO3 and extracted with DCM. The extract was dried (Na2SO4) and concentrated under vacuum to afford the title compound as a pale orange solid (1.4 g, 100%).

Workup

  1. temperatureunder reflux for 2 h
  2. temperatureto cool
  3. extractionextracted with DCM
  4. dry with materialThe extract was dried (Na2SO4)
  5. concentrationconcentrated under vacuum

Sources & evidence

ORD record
ord-41808262877a4ec3ab2ce1bda0b03c5a
Source dataset
uspto-grants-2004_06
Patent number
US06747030B1

Reaction notes

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