Water → HCID 23694151, compound

HRID 352879Notes

Reaction equation

HRID 352879 reaction equation
[C:1]([O:5][C:6]([CH:8]1[NH:13][CH2:12][C:11]2[O:14][C:15]([C:17]([O:19]C)=[O:18])=[N:16][C:10]=2[CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].O.[OH-].[Li+:23]>O1CCCC1>[C:1]([O:5][C:6]([CH:8]1[NH:13][CH2:12][C:11]2[O:14][C:15]([C:17]([O-:19])=[O:18])=[N:16][C:10]=2[CH2:9]1)=[O:7])([CH3:4])([CH3:2])[CH3:3].[Li+:23]

Participants

5

Reactant 3

HCID 962WaterHCID 3939Lithium HydroxideHCID 22709528HCID 22709528, compound

Product 1

HCID 23694151HCID 23694151, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

To a solution of 6-(tert-butoxycarbonyl)-2-methoxycarbonyl-4,5,6,7-tetrahydrooxazolo[5,4-c]pyridine (311 mg) in tetrahydrofuran (8.0 ml) were added water (2.0 ml) and lithium hydroxide (25.0 mg) at room temperature. After stirring for 10 minutes, the reaction mixture was distilled under reduced pressure to remove the solvent, whereby the title compound (280 mg) was obtained as a colorless solid. The residue was provided for the subsequent reaction without purification.

Workup

  1. distillationthe reaction mixture was distilled under reduced pressure
  2. customto remove the solvent, whereby the title compound (280 mg)
  3. customwas obtained as a colorless solid
  4. customThe residue was provided for the subsequent reaction without purification

Sources & evidence

ORD record
ord-6d442c26d3cc4987a786a57e33665155
Source dataset
uspto-grants-2004_06
Patent number
US06747023B1

Reaction notes

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