Methyl Acrylate → Propionic acid, 3-(pyrrolidin-1-yl)-, methyl ester

HRID 353012Notes

Reaction equation

HRID 353012 reaction equation
[NH:1]1[CH2:5][CH2:4][CH2:3][CH2:2]1.[C:6]([O:10][CH3:11])(=[O:9])[CH:7]=[CH2:8]>>[N:1]1([CH2:8][CH2:7][C:6]([O:10][CH3:11])=[O:9])[CH2:5][CH2:4][CH2:3][CH2:2]1

Participants

3

Reactant 2

HCID 7294Methyl AcrylateHCID 31268Pyrrolidine

Product 1

HCID 89167Propionic acid, 3-(pyrrolidin-1-yl)-, methyl esterYield 95%

Procedure

Pyrrolidine, 71.1 g, was added to 86.1 g of methyl acrylate at 20° C. and reacted for 24 hours. Purification by vacuum distillation yielded 149 g of methyl 3-(1-pyrrolidinyl)propionate, designated [B-17] (boiling point: 74° C./800 Pa, yield: 95%).

Workup

  1. customreacted for 24 hours
  2. customPurification
  3. distillationby vacuum distillation

Sources & evidence

ORD record
ord-5b6a9a63597543de8c3263fa00753206
Source dataset
uspto-grants-2004_06
Patent number
US06749988B2

Reaction notes

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