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HRID353179

反应详情

EQUATION

反应方程式

HRID 353179 的结构方程式

REACTANTS

反应物

4
结构：CCOC(=O)CBr
HCID7748

Ethyl bromoacetate

C4H7BrO2

结构：CCN(CC)CC
HCID8471

Triethylamine

C6H15N

结构：CCOC(C)=O
HCID8857

Ethyl acetate

C4H8O2

结构：CC(C)(C)OC(=O)C(C)(C)Sc1ccc(CCNCc2ccco2)cc1
HCID22708149

未命名化合物

PRODUCTS

生成物

1
结构：CCOC(=O)CN(CCc1ccc(SC(C)(C)C(=O)OC(C)(C)C)cc1)Cc1ccco1
HCID22708226

未命名化合物

收率 46.8%

AUXILIARIES

试剂、催化剂与溶剂

3
结构：CCCC[N+](CCCC)(CCCC)CCCC.[I-]
催化剂HCID67553

Tetrabutylammonium Iodide

C16H36IN

结构：O
溶剂HCID962

Water

H2O

结构：C1CCOC1
溶剂HCID8028

Tetrahydrofuran

C4H8O

PROCEDURE

实验过程

2.4 g of 1,1-dimethylethyl 2-[[4-[2-[(2-furanylmethyl)amino]ethyl]phenyl]thio]-2-methyl-propanoate, 1.5 g of ethyl bromoacetate, 0.97 g of triethylamine and 7.08 g of tetra-n-butylammonium iodide are dissolved in 100 ml of tetrahydrofuran and heated at reflux overnight. Ethyl acetate and water are added, and the mixture is extracted with water and sat. NaCl solution. Concentration and chromatography (petroleum ether/ethyl acetate 10+1) gives 1.38 g of the title compound.

WORKUP

后处理

  1. temperatureheated
  2. temperatureat reflux overnight
  3. extractionthe mixture is extracted with water and sat. NaCl solution
  4. concentrationConcentration and chromatography (petroleum ether/ethyl acetate 10+1)