反应详情

N-Bromosuccinimide (3.5 g, 19.7 mmol) was added to a solution (60 ml) of 2-amino-6-(2-furyl)nicotinonitrile (4.0 g, 21.6 mmol) in N,N-dimethylformamide in a nitrogen atmosphere at 1 to 2° C., followed by stirring as it was. After 30 minutes, the reaction solution was diluted with ethyl acetate and an aqueous saturated solution of potassium carbonate. The organic layer was washed with an aqueous saturated solution of potassium carbonate and an aqueous saturated solution of ammonium chloride, then dried over anhydrous sodium sulfate and concentrated. Methanol was added to the residue, and the resulting solid was collected by filtration and washed with methanol, to give the title compound (3.02 g, 53%) as a brown solid.

1. washThe organic layer was washed with an aqueous saturated solution of potassium carbonate
2. dry with materialan aqueous saturated solution of ammonium chloride, then dried over anhydrous sodium sulfate
3. concentrationconcentrated
4. additionMethanol was added to the residue
5. filtrationthe resulting solid was collected by filtration
6. washwashed with methanol