反应详情

温度

180 °C

1.07 g of 5,5-dimethoxy-1,2,3,4-tetrachlorocyclopenta-1,3-diene, 0.34 g of sodium hydrogen carbonate, 0.50g of trans-1-(3-methylisoxazol-5-yl)-1-propene and 0.05 g of hydroquinone were mixed and heated with stirring at 180° C. for 7 hours. The reaction solution was cooled and ethyl acetate was added. Insoluble matter was removed by filtration. Then the solvent was concentrated under reduced pressure. The obtained crude product was purified on silica gel column chromatography (elution with benzene) to give 0.70 g of the title compound as a mixture of isomers.

1. temperatureheated
2. temperatureThe reaction solution was cooled
3. customInsoluble matter was removed by filtration
4. concentrationThen the solvent was concentrated under reduced pressure
5. customThe obtained crude product
6. customwas purified on silica gel column chromatography (elution with benzene)