反应详情

A mixture containing 9.6 g (0.04 mole) of 2-phenyl-4-chloroquinazoline, 6.4 g. (0.04 mole) of 1-(2-pyridyl) piperazine and 250 ml of isopropanol was refluxed for 4 hrs. The resulting reaction mixture was filtered after cooling to room temperature. The crystalline solid was dissolved in 400 ml of 3 N hydrochloric acid and the aqueous acidic liquid was washed with ether. The aqueous layer was adjusted to pH=7.5 which precipitated crystalline solid. This acidification and basification were repeated once. Yield of product was 6.8 g, m.p. 164°-166° C. (air dried).

1. customThe resulting reaction mixture
2. filtrationwas filtered
3. dissolutionThe crystalline solid was dissolved in 400 ml of 3 N hydrochloric acid
4. washthe aqueous acidic liquid was washed with ether
5. customprecipitated crystalline solid
6. custom6.8 g, m.p. 164°-166° C. (air dried)