反应详情

A mixture of 30 parts of 3-[(2-amino-4-chlorophenyl)amino]-1-propanol, 20 parts of propanoic acid and 200 parts of a hydrochloric acid solution 4 N is stirred and refluxed for 3 hours. The reaction mixture is cooled, water and crushed ice are added and the whole is treated with activated charcoal. The latter is filtered off and the filtrate is alkalized with ammonium hydroxide. The product is extracted with methylbenzene. The extract is dried, filtered and evaporated. The residue is crystallized from 4-methyl-2-pentanone. The product is filtered off and dried, yielding 5-chloro-2-ethyl-1H-benzimidazole-1-propanol.

1. temperaturerefluxed for 3 hours
2. temperatureThe reaction mixture is cooled
3. additionare added
4. filtrationThe latter is filtered off
5. extractionThe product is extracted with methylbenzene
6. customThe extract is dried
7. filtrationfiltered
8. customevaporated
9. customThe residue is crystallized from 4-methyl-2-pentanone
10. filtrationThe product is filtered off
11. customdried