2(3H)-Benzoxazolone → HCID 12961163, compound

HRID 355032Notes

Reaction equation

HRID 355032 reaction equation
[H-].[Na+].[O:3]1[C:7]2[CH:8]=[CH:9][CH:10]=[CH:11][C:6]=2[NH:5][C:4]1=[O:12].[CH2:13]([O:15][C:16](=[O:25])[CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23]Br)C>CN(C=O)C>[CH3:13][O:15][C:16](=[O:25])[CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][N:5]1[C:6]2[CH:11]=[CH:10][CH:9]=[CH:8][C:7]=2[O:3][C:4]1=[O:12]

Participants

5

Reactant 3

HCID 60432(3H)-BenzoxazoloneHCID 24758Sodium hydrideHCID 264813Ethyl 8-bromooctanoate

Product 1

HCID 12961163HCID 12961163, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

The product is produced as described in example 1 from 3.0 g. of NaH (80% suspension in mineral oil), 13.5 g. of benzoxazolin-2-one, 200 cc. of DMF, 23.7 g. of 8-bromocaprylic acid ethyl ester and 3.0 g. of NaJ. Eluant in chromatographic purification: hexane/ethyl acetate.

Workup

  1. customThe product is produced
  2. customEluant in chromatographic purification

Sources & evidence

ORD record
ord-a613b0c8aa5a4d349fe13179d522a3b6
Source dataset
uspto-grants-1983_03
Patent number
US04377695

Reaction notes

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