Sodium hydride → HCID 54164349, compound

HRID 355044Notes

Reaction equation

HRID 355044 reaction equation
[H-].[Na+].[CH3:3][O:4][C:5](=[O:23])[CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][N:13]1[C:17]2[CH:18]=[CH:19][CH:20]=[CH:21][C:16]=2[NH:15][C:14]1=[O:22].COC(=O)[CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH2:33]Br>CN(C=O)C>[CH3:3][O:4][C:5](=[O:23])[CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][N:13]1[C:17]2[CH:18]=[CH:19][CH:20]=[CH:21][C:16]=2[N:15]([CH2:33][C:32]2[CH:27]=[CH:28][CH:29]=[CH:30][CH:31]=2)[C:14]1=[O:22]

Participants

5

Reactant 3

HCID 24758Sodium hydrideHCID 11107373Methyl 8-bromooctanoateHCID 129611718-(2-Oxobenzimidazolin-1-yl)-caprylic acid methyl ester

Product 1

HCID 54164349HCID 54164349, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

The product is produced as described in example 1 from 0.75 g. of NaH (80% suspension in mineral oil), 5.6 g. of 1-benzylbenzimidazolin-2-one (produced in usual manners by alkylation of benzimidazolin-2-one with benzylchloride according to example 8), 50 cc. of DMF, 5.9 g. of 8-bromocaprylic acid methyl ester and 0.75 g. of NaJ.

Workup

  1. customThe product is produced

Sources & evidence

ORD record
ord-fdb769078caf46fbb94c01b9cc831d09
Source dataset
uspto-grants-1983_03
Patent number
US04377695

Reaction notes

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