Hydrochloric Acid → HCID 18941005, compound

HRID 356125Notes

Reaction equation

HRID 356125 reaction equation
C(OC([NH:8][CH:9]1[CH2:13][CH2:12][CH2:11][CH:10]1[C:14]1[S:15][C:16]2[CH2:25][C:24]3[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=3[C:17]=2[N:18]=1)=O)(C)(C)C.[ClH:26]>C(OCC)(=O)C>[ClH:26].[ClH:26].[NH2:8][CH:9]1[CH2:13][CH2:12][CH2:11][CH:10]1[C:14]1[S:15][C:16]2[CH2:25][C:24]3[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=3[C:17]=2[N:18]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 18941067HCID 18941067, compound

Product 1

HCID 18941005HCID 18941005, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent2×

Procedure

In 6 ml of ethyl acetate, 155 mg of 2-[2-(tert-butoxycarbonylamino)cyclopentyl]-8H-indeno[1,2-d]thiazole was dissolved. Then, 15 ml of a 4N solution of hydrogen chloride in ethyl acetate was added, followed by stirring at room temperature for one hour. The crystals precipitated were collected by filtration, and the crystals were recrystallized from ethyl acetate-methanol, whereby 39 mg of 2-(2-aminocyclopentyl)-8H-indeno[1,2-d]thiazole dihydrochloride was obtained.

Workup

  1. customThe crystals precipitated
  2. filtrationwere collected by filtration
  3. customthe crystals were recrystallized from ethyl acetate-methanol

Sources & evidence

ORD record
ord-98a72273ce0240338438f7399de49df3
Source dataset
uspto-grants-1998_11
Patent number
US05834499

Reaction notes

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