反应详情

A mixture of 2.0 g of N-[3-(3-methyl-1,2,4-triazolo[4,3-b]pyridazin-6-yl)phenyl]cyclobutanecarboxamide and 0.36 g of sodium hydride (50% in oil) in 200 ml of dry dimethylformamide, under argon, was stirred for 1 hour, then 0.6 ml of ethyl iodide was added. This mixture was stirred overnight, then poured into 200 ml of water and extracted with dichloromethane. The extracts were combined, dried and evaporated in vacuo. The residue was chromatographed on a silica gel column, eluting with dichloromethane:methanol (97:3). The fractions containing product were combined and evaporated, giving 0.81 g of the desired compound as yellow crystals, mp 157°-159° C.

1. stirringThis mixture was stirred overnight
2. extractionextracted with dichloromethane
3. customdried
4. customevaporated in vacuo
5. customThe residue was chromatographed on a silica gel column
6. washeluting with dichloromethane:methanol (97:3)
7. additionThe fractions containing product
8. customevaporated