Dimethylformamide → N-Methyl-N[3-(3-methyl-1,2,4-triazolo[4,3-b]pyridazin-6-yl)phenyl]formamide

HRID 35641Notes

Reaction equation

HRID 35641 reaction equation
[CH3:1][C:2]1[N:6]2[N:7]=[C:8]([C:11]3[CH:12]=[C:13]([NH:17][CH:18]=[O:19])[CH:14]=[CH:15][CH:16]=3)[CH:9]=[CH:10][C:5]2=[N:4][N:3]=1.[H-].[Na+].[CH3:22]N(C)C=O>>[CH3:22][N:17]([C:13]1[CH:14]=[CH:15][CH:16]=[C:11]([C:8]2[CH:9]=[CH:10][C:5]3[N:6]([C:2]([CH3:1])=[N:3][N:4]=3)[N:7]=2)[CH:12]=1)[CH:18]=[O:19]

Participants

4

Reactant 3

HCID 6228DimethylformamideHCID 24758Sodium hydrideHCID 15595683N-[3-(3-Methyl-1,2,4-triazolo-[4,3-b]pyridazin-6-yl) phenyl]formamide

Product 1

HCID 15595684N-Methyl-N[3-(3-methyl-1,2,4-triazolo[4,3-b]pyridazin-6-yl)phenyl]formamide

Procedure

A mixture of 2.5 g of N-[3-(3-methyl-1,2,4-triazolo-[4,3-b]-pyridazin-6-yl)phenyl]formamide, 0.56 g of sodium hydride (50% in oil) and 250 ml of dimethylformamide were reacted as described in example 2, giving 1.72 g of the desired product as a white powder, mp 207°-210° C.

Workup

  1. customwere reacted

Sources & evidence

ORD record
ord-92cf283ca8064e438ede5469e864ac9b
Source dataset
uspto-grants-1988_08
Patent number
US04767765

Reaction notes

Loading…