反应详情

2.9 ml benzyl alcohol was dissolved in 10 ml N,N-dimethylformamide and 0.7 g sodium hydride (purity 95%) was slowly added. After gas evolution has ceased, 6 g 2,6-dibromopyridine was added and the mixture heated to reflux for 3 hours. After cooling, the reaction mixture was filtered through a silica gel column using hexane/ethyl acetate 1/1. The solvent was removed in vacuo and the crude product purified by flash silica gel column chromatography. The title compound was obtained as a colourless oil.

1. temperaturethe mixture heated
2. temperatureto reflux for 3 hours
3. temperatureAfter cooling
4. filtrationthe reaction mixture was filtered through a silica gel column
5. customThe solvent was removed in vacuo
6. customthe crude product purified by flash silica gel column chromatography