反应详情

A solution of methyl 3-hydroxy-4-nitrobenzoate (5.9 g) in dimethylformamide (40 mL) is treated with potassium carbonate (6.2 g) and 2-bromopropane (3.7 g), and the stirred solution is heated at 60°-65° C. for 4 hours. After cooling, water (100 mL) is added and the solution is extracted with toluene (2×100 mL) The combined organic extracts are dried over magnesium sulfate and evaporated in vacuo, to give methyl 3-isopropoxy-4-nitrobenzoate, in the form of a pale yellow solid (5.9 g), m.p. 46°-48° C.

1. temperaturethe stirred solution is heated at 60°-65° C. for 4 hours
2. temperatureAfter cooling
3. extractionthe solution is extracted with toluene (2×100 mL) The combined organic extracts
4. dry with materialare dried over magnesium sulfate
5. customevaporated in vacuo