Hydrochloric Acid → HCID 20450002, compound

HRID 358046Notes

Reaction equation

HRID 358046 reaction equation
[NH2:1][CH2:2][C:3]1[N:7]2[C:8]3[CH:23]=[CH:22][C:21]([Cl:24])=[CH:20][C:9]=3[C:10]([C:13]3[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=3[F:19])=[CH:11][CH2:12][C:6]2=[N:5][N:4]=1.Cl>C(O)(C)C>[ClH:24].[NH2:1][CH2:2][C:3]1[N:7]2[C:8]3[CH:23]=[CH:22][C:21]([Cl:24])=[CH:20][C:9]=3[C:10]([C:13]3[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=3[F:19])=[CH:11][CH2:12][C:6]2=[N:5][N:4]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 20449954HCID 20449954, compound

Product 1

HCID 20450002HCID 20450002, compound

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent2×

Procedure

For conversion into the hydrochloride, the base is dissolved in isopropanol and treated with an equivalent amount of hydrogen chloride in isopropanol. After evaporation of the solvent and recrystallization of the hydrochloride from a ten-fold amount of water, there is obtained 1-(aminomethyl)-8-chloro-6-(2-fluorophenyl)-4H-s-triazolo[4,3-a][1]benzazepine hydrochloride of melting point 246°-248° (decomposition).

Workup

  1. customAfter evaporation of the solvent and recrystallization of the hydrochloride from a ten-fold amount of water

Sources & evidence

ORD record
ord-e79accdc60704547946bf448e210c294
Source dataset
uspto-grants-1984_08
Patent number
US04464300

Reaction notes

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