Hydrazine hydrate (1:1) → HCID 20449960, compound

HRID 358069Notes

Reaction equation

HRID 358069 reaction equation
O.[NH2:2][NH2:3].[Cl:4][C:5]1[CH:6]=[CH:7][C:8]2[NH:14][C:13](=S)[CH2:12][CH2:11][CH:10]([C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=3[F:22])[C:9]=2[CH:23]=1>O1CCCC1>[Cl:4][C:5]1[CH:6]=[CH:7][C:8]2[NH:14][CH:13]([NH:2][NH2:3])[CH2:12][CH2:11][CH:10]([C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=3[F:22])[C:9]=2[CH:23]=1

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 20450012HCID 20450012, compound

Product 1

HCID 20449960HCID 20449960, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

A solution of 17.5 ml of hydrazine hydrate in 1.75 l of tetrahydrofuran is treated with 22 g of 7-chloro-5-(2-fluorophenyl)-1,3,4,5-tetrahydro-2H-1-benzazepine-2-thione. The solution is stirred under a stream of argon for 2 hours and then evaporated at 40° in vacuo. The residue is crystallized from ether and there is obtained 7-chloro-5-(2-fluorophenyl)-2-hydrazino-4,5-dihydro-2H-1-benzazepine of melting point 213°-215°.

Workup

  1. customevaporated at 40° in vacuo
  2. customThe residue is crystallized from ether

Sources & evidence

ORD record
ord-d4d528c3364f41c2b739c5a22cb9bdf5
Source dataset
uspto-grants-1984_08
Patent number
US04464300

Reaction notes

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